Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. 7th and 8th day got evan better. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. Use memantine regularly to get the most benefit. Yeah it was definitely as rapid of a reaction as one could possibly hope for. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. The memantine dosage will differ based on the use case. I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. I felt constantly down, anxious, and helpless. This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. I'm also diagnosed with ADHD (in addition to other and suspected psychiatric conditions), and Adderall didn't induce a mood episode for me--though, I was taking (and still take) a mood stabilizer when I started. I tried up to 5 mg but that would give me anxiaty few hours after ingesting, and possible diso feeling tomorow. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. It just seemed like anxiety was my biggest issue, as I was seemingly always one piece of bad news from having a nervous breakdown. It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. A bit of background, I'm a 24 year old male premed student. I dont remember why i stoped again, but i noticed big depresion is not coming back, so i let 1 month to pass without taking m. And im still CDFree. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. Its as if all the background noise in my head just suddenly had been silenced. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. “I’ve been taking 5mg of memantine before bed and it has been doing wonders for my anxiety and depression. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. What I didn't expect was that I would no longer need the Adderall. This is my experience with Memantine. Those that do have at least light/mild effect are: Nac for working memory. I did not find the it to be a very recreational drug but I did feel pretty great the next day mentally. For more of my own personal experiences, … Has anybody had long term success with memantine? Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. Feel free to share yours. There's preliminary research supporting its use in bipolar disorder, particularly for mood stabilization and cognitive functioning. Any help is apriciated. I have strainght to go outside. Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. Ill ask about lamotrigine, but I'm reluctant to switch off of memantine given how effective its been for me thus far. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I'm sorry to hear that, my respond to it has been nothing short of incredible. By using our Services or clicking I agree, you agree to our use of cookies. u/bluesatin is right: your reaction to the antidepressant is typical of those with bipolar disorder. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. On the other hand, sounds like ADD as well, as you mentioned. This sub is not for venting or for facebook style posts. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. The severity of the condition will also influence how much Memantine to take. Our … Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. From novel/alternative substances, to established medications. Almost all year i had no power to evan roll in bed, tho i was fighting it. It's primarily used to protect against future episodes of depression, and it's quite tolerable. I'm jealous of Memantine responders. Memantine is great. 23y.student Sory for bad eng, nonnative speaker. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. Press question mark to learn the rest of the keyboard shortcuts. stoped memantine third time - CD free 1m and counting. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Since trying the memantine, my use of caffeine has almost tapered itself. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Memantine Dosage. Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. stoped memantine twice-CD came back. Aniracetam helped with my speach problems, writing, remebering words, names, making gramaticly corect sentences (al least in my native language haha). In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Depression; Memantine Dosage. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. I talked him into prescribing me Lexapro and Adderall at 10 mg and 20 mg respectively, on top of Buproprion 300mg. And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. That said, there are side effects to rapid remission of CD. Should i take memantine again, or some other stuff that effects NMDA, like magnesium l threonate, agmatin sulfate? In a previous pre-clinical … It's just something you might want to bear in mind. Memantine may be useful for treating substance abuse and dependence. Press question mark to learn the rest of the keyboard shortcuts. Larger-scale, randomized controlled trials are necessary before one … Another good thing is it doesnt give me brain fog i was scared of. My question is: How long do I need to wait until I can start dosing therapeutically? Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. I'd be curious to know what sort of neurologic differences are consistent with someone like me who does respond to it very well. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. If you had an extremely quick response to an SSRI, it might be related to Bipolar disorder by the way; it's now commonly advised for Bipolar patients to stay away from SSRIs due to the ability for it to trigger hypomanic/manic symptoms and generally destabilise mood. ADHD is also commonly comorbid with BD; moreover, the neurocognitive deficits among bipolar patients are well-documented in the literature, and they notably resemble those of ADHD patients. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Age and the condition you are treating are key determinants. memantine. But of course, me just saying shit diagnosing things online is easily said but with very background behind it all. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. From studies and experiences, CD that responds to dissociatives does not tend to reappear later on, so you should be good. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). I think it would be prudent to meet with a psychiatrist, if only to rule out BD. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. One of those downswings came around 4 months ago. Press J to jump to the feed. psychomotor retardation is horrible stinky crap. Little things bothered me more than they should've. Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. 6 days after first dose i noticed im less depressed. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. I dont mind those sideefects too much, they are liveable, CD not so much. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. Cookies help us deliver our Services. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA). By blocking NMDA receptors, mema… From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Several factors will determine the amount of Memantine one should take. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. Im scared CD is gonna come back, what if memantine will not work then? Memantine increases cognitive effects dose-dependently in the absence of the AChE-I and the slope (in % correct on the 2-back WM test for 0–40 mg of memantine) of 0.08 is increased to 0.23 and 0.34 when adding donepezil 5 and 10 mg, respectively. I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. Im also on cymbalta 30 mg(uper dose doesnt feel any different). Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. Magnetic resonance … Get your prescription refilled before you run out of medicine completely. Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. Memantine again, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a rapidly acting treatment for treatment-resistant Major (... Would no longer need the Adderall, i 'm not entirely sure why but... To hear that, my respond to it has been nothing short of incredible there are side to. 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